Me Gusta is a minimum 4-pane meme used to display a mildly disturbing and at the same time funny face. The face is mostly used for awkward ways to like something or something pervert.
There are several spin-offs for this meme, like No Me Gusta and Me Gusta Mucho.
No Me Gusta is used to awkwardly dislike something, and Me Gusta Mucho is the same as Me Gusta but with a pervert big smile.