Me and the Boys is a snowclone caption used in memes about various activities. Originally popular as a hashtag and a non-ironic caption, in early 2019 the phrase, paired with non-sequitur followups, gained popularity in /r/okbuddyretard subreddit and on Instagram, gaining mainstream attention with 60's Spiderman villains variations in late May 2019.
Origin 
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While the exact origin of the phrase is unknown, before 2019 "Me and my boys" has been often used as a title for photograph posts on Facebook, Twitter, Instagram, Reddit and other social platforms.
Spread Edit
On November 7th, 2018, Redditor calogant reposted an older image of several popular characters holding copies of the Holy Bible in church with a caption "Me and the Boys at bible study" to /r/okbuddyretard subreddit.
Within 24 hours, the submission was reposted on /r/memes and /r/me_irl subreddits, gaining over 4,900 and 35,000 upvotes in two weeks, respectively. On January 23rd, 2019, Redditor RadicalCars posted another version of the meme to /r/okbuddyretard garnering over 11,600 upvotes in one week.
60's Spider-Man Villains Variations Edit
On May 25th, 2019, Redditor cobe1712 edited an image of 60's Spider-Man Rhino into a still image from episode 19 "To Catch a Spider / Double Identity" of 1967 animated TV series Spider-Man showing characters Vulture, Electro and Green Goblin smiling.
