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"Run, Forrest, Run!" is a meme that originated from the movie, Forrest Gump. When the bullies were chasing Forrest, Jenny started yelling, "run, forrest, run!" and this helped Forrest run faster away from the bullies. This eventually led Forrest being able to run across the country many times when he was an adult.
Now, people use this quote a lot when they see someone running fast, especially if it looks like they are trying to get to somewhere on time. This can also be said if someone, like Forrest, is trying to run away from bullies or other people.